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Creators/Authors contains: "Gomez-Martinez, Ismael"

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  1. ; ; ; ; ; ; ; ; (, American Journal of Physiology-Gastrointestinal and Liver Physiology)
    Novel human colonocyte monolayer cultures, benchmarked by transcriptomics for physiological relevance, detect early cytopathic impacts of Clostridioides difficile toxins TcdA and TcdB. A fluorescent ZO-1 reporter in primary human colonocytes is used to track epithelial barrier disruption in response to TcdA. Basal TcdA/B exposure generally caused more rapid onset and cytotoxicity than apical exposure. Transcriptomics demonstrate changes in tight junction, chemokine, and cytokine receptor gene expression post-TcdA exposure. Diclofenac-induced leaky epithelium enhanced apical exposure toxicity. 
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  2. ; ; ; ; ; ; ; ; ; (, Cellular and Molecular Gastroenterology and Hepatology)
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